万茜淋,吴新民,杨雪,刘馨泽,王琦,李玉

• 1:长春中医药大学吉林省人参科学研究院
• 2:吉林农业大学食药用菌教育部工程研究中心
• 3:吉林大学第一医院神经肿瘤外科
• 4:长春中医药大学附属医院

摘要(Abstract)：

对桑黄孔菌属的分类地位进行梳理和明确，并就桑黄孔菌属内物种的化学成分种类及药理作用的研究进展进行归纳总结。以“桑黄、化学成分、活性、药理作用”等为关键词，检索1960—2020年Web of Science、PubMed、中国知网和中国万方等数据库中桑黄的相关文献，总结了桑黄的化学成分及药理活性研究进展。检索筛选中文文献240篇，外文文献102篇，发现桑黄中含有的化学成分种类及含量丰富，药理作用广泛，包括抗肿瘤作用、抗氧化作用、抗病毒、增强免疫功能、降血糖和降尿酸作用等。通过对中药桑黄的化学成分及其药理作用的归类整理，为深入研究桑黄及其配伍应用、开拓药用范围并明确药效机制等研究打开新思路。

关键词(KeyWords)： 桑黄;化学成分;活性;药理作用;研究进展

Abstract:

Keywords:

基金项目(Foundation): 吉林省教育厅科学技术研究项目（JJKH20220876KJ）;; 吉林省中医药科技项目（2021003）

作者(Author): 万茜淋,吴新民,杨雪,刘馨泽,王琦,李玉

DOI: 10.13341/j.jfr.2022.1431

参考文献(References)：

• [1]李玉，李泰辉，杨祝良，等.中国大型菌物资源图鉴[M].郑州：中原农民出版社，2016:466-484.
• [2]吴声华，黄冠中，陈愉萍，等.桑黄的分类及开发前景[J].菌物研究，2016,14(4):187-200,185.
• [3]杨全，胡旭光，王琦，等.药用真菌桑黄菌丝体多糖抗肿瘤作用的研究[J].中国中药杂志，2006,20:1713-1715.
• [4]郑威.弱磁场辅助桑黄液体发酵的响应规律研究[D].南京：江苏大学，2017.
• [5]李玉，包海鹰.中国菌物药[M].郑州：中原农民出版社，2020:151-235.
• [6]Wan X,Jin X,Wu X,et al.Structural characterisation and antitumor activity against non-small cell lung cancer of polysaccharides from Sanghuangporus vaninii[J].Carbohydr Polym,2022,276:118798.
• [7]Ikekawa T,Nakanishi M,Uehara N,et al.Antitumor action of some basidomycetes,especially Phellinus linteus[J].Gann,1968,59:155-157.
• [8]包海鹰，王超儀，图力古尔."桑黄"的本草考证[J].菌物学报，2013,32(s1):70-78.
• [9]Wu S H,Chang C C,Wei C L,et al.Sanghuangporus toxicodendri sp.nov.from China Sanghuangporus toxicodendri sp.nov.(Hymenochaetales,Basidiomycota)from China[J].Myco Keys,2019,57:101-111.
• [10]Zhang Z,Lv G,Cheng J,et al.Characterization and biological activities of polysaccharides from artificially cultivated Phellinus baumii[J].Int J Biol Macromol,2019,129:861-868.
• [11]Ota K,Yamazaki I,Saigoku T,et al.Phellilane L,sesquiterpene metabolite of Phellinus linteus:Isolation,structure elucidation,and asymmetric total synthesis[J].J Org Chem,2017,82:12377-12385.
• [12]Jiang F C,Zhang H N,Wu D,et al.Kinetic models for the effect of temperature on flavonoid production in liquid submerged fermentation by Phellinus baumii[J].Biotechnol Appl Biochem,2018,65:739-747.
• [13]Yeo W H,Hwang E I,So S,et al.Phellinone,a new furanone derivative from the Phellinus linteus KT&G PL-2[J].Arch Pharm Re S,2007,30:924-926.
• [14]Lee Y S,Kang Y H,Jung J Y,et al.Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus[J].Biol Pharm Bull,2008,31:765-768.
• [15]Lin C J,Lien H M,Chang H Y,et al.Biological evaluation of Phellinus linteus-fermented broths as anti-inflammatory agents[J].J Biosci Bioeng,2014,118:88-93.
• [16]Huang S C,Wang P W,Kuo P C,et al.Hepatoprotective principles and other chemical constituents from the mycelium of Phellinus linteus[J].Molecule S,2018,23:1705.
• [17]Lee S,Lee D,Jang T S,et al.Anti-inflammatory phenolic metabolites from the edible fungus Phellinus baumii in LPS-Stimulated RAW264.7 cells[J].Molecule S,2017,22:E1583.
• [18]Huang S C,Kuo P C,Hung H Y,et al.Ionone derivatives from the mycelium of Phellinus linteus and the inhibitory effect on activated rat hpatic stellate cells[J].Int J Mol Sci,2016,17:681.
• [19]Song T Y,Yang N C,Chen C L,et al.Protective effects and possible mechanisms of ergothioneine and hispidin against methylglyoxal-induced injuries in rat pheochromocytoma cells[J].Oxid Med Cell Longev,2017(2017):1-10.
• [20]Ye L,Zheng H,Zhang Z,et al.Preparative isolation of 5 antioxidant constituents from the medicinal mushroom Phellinus baumii(Agaricomycetes)by high-speed countercurrent chromatography and preparative high-performance liquid chromatography[J].Int J Med Mushroom S,2017,19:319-326.
• [21]葛青.桑黄子实体多糖的分离纯化、结构鉴定及结构修饰研究[D].杭州：浙江工业大学，2009.
• [22]Jia X,Gao M,Li M,et al.Molecular characterization of two polysaccharides from Phellinus vaninii Ljup and their anti-tumor activities[J].Anti-cancer Agents in Medicinal Chemistry,2017,17(9）.
• [23]吴长生.药用真菌桑黄化学成分的研究[D].济南：山东大学，2011.
• [24]李有贵，钟石，计东风.野生与人工栽培桑黄子实体中的粗多糖和粗酚含量及药用活性比较[J].蚕业科学，2016,42(5):883-891.
• [25]Park I H,Chung S K,Lee K B,et al.An antioxidant hispidin from the mycelial cultures of Phellinus linteus[J].Arch Pharm Re S,2004,27(6):615-618.
• [26]Zhang H N,Shao Q,Wang W H,et al.Characterization of compounds with tumor-cell proliferation inhibition activity from mushroom(Phellinus baumii)mycelia produced by solid-State fermentation[J].Molecules,2017,22:698.
• [27]冯娜，吴娜，杨焱，等.鲍姆木层孔菌子实体中化合物的结构鉴定及其抗肿瘤活性[J].菌物研究，2013,11(2):150.
• [28]张林芳.桑黄总三萜分离纯化及其抗肿瘤机制研究[D].哈尔滨：东北林业大学，2016.
• [29]韩东岐，吴海涛，王铁杰，等.桑黄纤孔菌发酵液化学成分的研究[J].中成药，2018,40(1):126-129.
• [30]Dobrijevi?Z,Matija?evi?S,I?i?Den?i?T,et al.Association between genetic variants in DICER1 and cancer risk:An updated meta-analysi S[J].Gene,2021,15(766):145132.
• [31]Lee S H,Hwang H K,Kang C M,et al.Potential impact of Phellinus linteus on adherence to adjuvant treatment after curative resection of pancreatic ductal adenocarcinoma:outcomes of a propensity score-matched analysis[J].Integr Cancer Ther,2019,18:1534735418816825.
• [32]Sliva D.Medicinal mushroom Phellinus linteus as an alternative cancer therapy[J].Exp Ther Med,2010,1(3):407-411.
• [33]Kojima H,Tanigawa N,Kariya S,et al.A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases[J].Radiat Med,2006,24(2):139-142.
• [34]Lee I K,Seo G S,Jeon N B,et al.Phellinins A1 and A2,new styrylpyrones from the culture broth of Phellinus sp.KACC93057P:I.Fermentation,taxonomy,isolation and biological properties[J].J Antibiot,2009,62(11):631-634.
• [35]夏国华.桑黄黄酮类成分及制剂研究[D].南京：江苏大学，2010.
• [36]Im K H,Baek S A,Choi J,et al.Antioxidant,anti-melanogenic and anti-wrinkle effects of Phellinus vaninii[J].Mycobiology,2019,47(4):494-505.
• [37]Wang T W,Sun S W,Liang C,et al.Effective isolation of antioxidant Phelligridin LA from the fermentation broth of Inonotus baumii by macroporous resin[J].Bioprocess Biosyst Eng,2020,43(11):2095-2106.
• [38]Dai Y C,Zhou L W,Cui B K,et al.Current advances in Phellinus sensu lato:medicinal species,functions,metabolites and mechanisms[J].Appl Microbiol Biotechnol,2010,87(5):1587-1593.
• [39]Chang Z Q,Oh B C,Lee S P,et al.Comparative immunomodulating activities of polysaccharides isolated from Phellinus spp.on cell-mediated immunity[J].Phytother Re S,2008,22(10):1396-1399.
• [40]Sung S K,Batbayar S,Lee D H,et al.Activation of NADPHOxidase byβ-Glucan from Phellinus baumii(Agaricomycetes)in RAW 264.7 Cells[J].Int J Med Mushroom S,2017,19(11):957-965.
• [41]Zhong S,Ji D F,Li Y G,et al.Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells[J].Chem Biol Interact,2013,206(2):222-229.
• [42]Hwang B S,Lee I K,Choi H J,et al.Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii[J].Bioorg Med Chem Lett,2015,25(16):3256-3260.
• [43]Yang K,Zhang S,Ying Y,et al.Cultivated fruit body of Phellinus baumii:a potentially sustainable antidiabetic resource[J].ACS Omega,2020,5(15):8596-8604.
• [44]Kim D I,Kim K S,Kang J H,et al.Effect of Phellinus baumii-biotransformed soybean powder on lipid metabolism in rats[J].Prev Nutr Food Sci,2013,18(2):98-103.
• [45]赵立英，施维.桑黄提取物的抗癌及降尿酸作用机制研究[C].第十二届中国酶工程学术研讨会论文摘要集.长春：中国微生物学会酶工程专业委员会，2019.