李玲艳;包海鹰;

• 1:吉林农业大学中药材学院

摘要(Abstract)：

通过文献检索对云芝的化学成分及药理活性方面进行了综述。研究发现云芝含甾体类、三萜类、有机酸类、生物碱类、葡糖醇类、蛋白质类、糖类、糖肽类等29个化合物,还含胞外黏性物质(ECMM)、胃蛋白酶抑制剂、真菌激发子、铁黏合螯合剂、环肽、18种人体所需的氨基酸和维生素B1、B2、B6及铜、铁、钾、锌等10多种人体所需的活性微量元素等其他类化合物。云芝具有抗肿瘤、镇痛、治疗慢性乙型肝炎、降血脂和抗动脉粥样硬化、抗氧化、抗衰老、益气解毒、体外抗微生物活性等作用。

关键词(KeyWords)： 云芝;活性成分;药理作用

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金项目(30870013)

作者(Authors): 李玲艳;包海鹰;

DOI: 10.13341/j.jfr.2011.03.009

参考文献(References)：

• [1]国家药典委员会.中华人民共和国药典(一部)[M].中国医药科技出版社,2010.
• [2]祁永青,刁治民,刘涛.药用真菌云芝的研究概况[J].青海草业,2008,17(3):26-29.
• [3]Bi Cheng,Guo Xiaoyu,Che Qingming.Chemical constituents fromCoriolus versicolorL.[J].Journal of Chinese Pharmaceutical Sci-ences,2007(16):38-40.
• [4]米芳.白腐真菌云芝代谢产物的初步研究[D].杨凌:西北农林科技大学,2010.
• [5]Adams P,Lynch J M,De Leij F A A.Desorption of zinc by extra-cellularly produced metabolites ofTrichoderma harzianum,Tricho-derma reeseiandCoriolus versicolor[J].Journal of Applied Micro-biology,2007,103(6):2240-2247.
• [6]Liu Jinqing,Zhang Song,Mei Xiaodeng,et al.Antiaging effect ofbioactive compounds extracted from five species of mushrooms[J].Huanan Shifan Daxue Xuebao,2007(4):110-113.
• [7]Jeong S C,Yang B K,Ra K S,Wilson M A,Cho Y,Gu Y A,Song C H.Characteristics of anti-complementary biopolymer ex-tracted fromCoriolus versicolor[J].Carbohydrate Polymers,2004,55(3):255-263.
• [8]Martin V Dutton,Mona Kathiara,Imelda M Gallagher,Christine SEvans.Purification and characterization of oxalate decarboxylasefromCoriolus versicolor[J].FEMS Microbiology Letters,1994,116(3):321-325.
• [9]Christine S Evans,Jill Y Farmer,John M Palmer.An extracellularhaem-protein fromCoriolus versicolor[J].Phytochemistry,1984,23(6):1247-1250.
• [10]Paul J Dodson,Christine S Evans,Pat J Harvey,John M Palmer.Production and properties of an extracellular peroxidase[J].FEMSMicrobiology Letters,1987,42(1):17-22.
• [11]Shingo Kawai,Toshiaki Umezawa,Mikio Shimada,TakayoshiHiguchi.Aromatic ring cleavage of 4,6-di(tert-butyl)guaiacol,aphenolic lignin model compound,by laccase ofCoriolus versicolor[J].FEBS LETEERS,1988,236(2):309-311.
• [12]Masaaki Yoshiyama,Yoshio Itoh.Polyphenol oxidase productionin a jar fermentor byCoriolus versicolor[J].Journal of Fermenta-tion and Bioengineering,1994,78(2):188-190.
• [13]Naraoka Satoshi,Yamaguchi Shinya,Miyaki Hiroshi,UenoTakako,Funabashi Katsuyuki,Maruyama Kazutaka.A large scalepreparation of lignin peroxidase from white-rot fungus culture:JP,JP2007215431[P].2007-08-30.
• [14]Rosario Freixo Maria,Karmali Amin,Arteiro Jose Maria.Produc-tion of polygalacturonase fromCoriolus versicolorgrown on tomatopomace and its chromatographic behaviour on immobilized metalchelates[J].Journal of Industrial Microbiology&Biotechnology.2008,35(6):475-484.
• [15]Huang Zhili,Huang Yanjun,Zhang Lijun,Dang Jianzhang,Liang Shizhong.Purification of superoxide dismutase fromCorio-lus versicolormycelium[J].Shenzhen Zhiye Jishu Xueyuan Xue-bao,2009,8(3):50-52.
• [16]Tsukagosh S,Ohashi F Gann.Polysaccharide fromCoriolns versi-color[J].Cancer Therapy abst,1974,12(6):557.
• [17]张翼伸,李志平,苗春艳,石德成.云芝多糖的分离与鉴定[J].吉林师大学报:自然科学版,1979(2):108-115.
• [18]陈海生.野生云芝中水溶性糖的分离与鉴定[J].解放军药学报,2000,16(5):268.
• [19]Yang Q Y.Yunzhi Polysaccharopeptide(PSP)and the general as-pects of its research[J].Fung Sci,1997,12(1/2):1-8.
• [20]张品,邹巧根,宋品.云芝糖肽的单糖组成分析闭[J].中国药科大学学报,200l,32(2):137-140.
• [21]张志花,杨晓彤,方积年.云芝糖肽在高效液相凝胶柱上色谱行为的研究[J].色谱,1997,15(2):150-152.
• [22]朱丽玢.云芝糖肽高效毛细管电泳分析[J].中药材,2000,23(4):227.
• [23]王静,王晴,向文胜.色谱法在糖类化合物分析中的应用[J].分析化学,200l,39(2):222-227.
• [24]Yang Q Y,Hu Y J,LI X Y,et al.PSP intemational symposium[C].HongKong:FudanUniversity Press,1993:56-61.
• [25]朱丽粉,洪筱坤,王智华,等.毛细管区电泳分离云芝糖肤的方法学研究及其在市售糖肽类药物中的应用[J].中国中药杂志,2001,36(11):758-759.
• [26]雷引林,王晓东,刘坐镇,等.亲和层析纯化云芝糖肽[J].中成药,2001,23(1):8-10.
• [27]Vesentini Damiano,Dickinson David J,Murphy Richard J.Theprotective role of the extracellular mucilaginous material from twowood-rotting basidiomycetes against copper toxicity[J].Interna-tional Biodeterioration&Biodegradation,2007,60(1):1-7.
• [28]Ma Yamin,Tian Yaping.Study on ultrasonic extraction technolo-gy forCoriolus versicolorintracellular pepsin inhibitor[J].Sheng-wu Jishu,2008,18(5):46-48.
• [29]Wang Wenjun,Song Fajun,Sun Yafang.Effects of fungal andchemical elicitors on growth and carotenoid formation ofPhaffiarhodozyma[J].Zhongnan Minzu Daxue Xuebao,2008,27(2):14-17.
• [30]Wang Lu,Yan Wenchao,Chen Jiachuan,Huang Feng,Gao Pei-Ji.Function of the iron-binding chelator produced byCoriolus ver-sicolorin lignin biodegradation[J].Life Sciences,2008,51(3):214-221.
• [31]Shimokawa Kenichiro,Mashima Itsuka,Asai Akiko,YamadaKaoru,Kita Masaki,Uemura Daisuke.Ternatin,a highly N-methylated cyclic heptapeptide that inhibits fat accumulation:Structure and synthesis[J].Tetrahedron Letters,2006,47(26):4445-4448.
• [32]程培元.药用真菌云芝、香菇多糖、猴头的抗肿瘤作用[J].江苏医药,1978(11):40-43.
• [33]吴凯南,林辉,孔令泉,刘胜春,张震寰.云芝胞内多糖抑制肿瘤血管生成和移植性乳腺癌生长的实验研究[J].中华普通外国杂志,2001,16(2):124.
• [34]Ng T B.A review of research on the protein-bound polysaccharide(polysaccharopeptide,PSP)from the mushroomCoriolus versicolor(basidiomycetes:Polyporaceae)[J].General Pharmacology:TheVascular System,1998,30(1):1-4.
• [35]Kang D Maksimovic-Ivanic,Stojanovic I,Momcilovic M,Maksi-movic V,Tufegdzic S,Marjanovic Z,Mostarica-Stojkovic M,Vucinic Z,Stosic-Grujicic S.Anti-tumor effect ofCoriolus versi-colorError:figure isn′t in document methanol extract againstmouse B16 melanoma cells:In vitro and in vivo study[J].Foodand Chemical Toxicology,2008,46(5):1825-1833
• [36]邵伟,郝泗城,孙建华.云芝多糖对肝腹水小鼠生存期和腹水中癌细胞的动态影响[J].医药工业,2000,16(6):26-28.
• [37]陆陪新,王能进,张松平.AFB:建立大鼠肝癌模型以及云芝多糖对肝癌发生阻断作用的研究[J].肿瘤防治研究,1992,19(4):217-218.
• [38]周曾同,张水龙,赵亦非,金芝贵,杨庆尧.云芝精华(PSP)防治口腔白斑癌变的临床研究[J].临床口腔医学杂志,2001,17(2):133-134.
• [39]伊藤均.担子菌类の抗肿疡作用にフいて:担子菌カヮラケの产生する多糖体の抗肿疡作用[J].日药理志,1992,18(3):571-577.
• [40]曾淑君,沈宝莲,文良珍.复方云芝糖肽对裸鼠人鼻咽癌抗癌作用的研究[J].中药药理与临床,1994(5):35-37.
• [41]曾淑君,沈宝莲,文良珍.云芝糖肽对裸鼠人肺腺癌抗癌作用的研究[J].中国药理学通报,1995,11(1):46-48.
• [42]陈晓君,史泓浏,潘伟光.云芝抑瘤作用及其对癌组织端粒酶活性的影响[J].中华中医药杂志,2005(20):217-218.
• [43]吴凤兰,周羽立,张亚非,张明珠.云芝糖肽对裸鼠荷人肝癌的抑制作用[J].暨南大学学报,1994,15(4):1-4.
• [44]Ng T B,Chan W Y.Polysaccharopeptide from the mushroomCoriolus versicolorpossesses analgesic activity but does not pro-duce adverse effects on female reproductive or embryonic develop-ment in mice[J].General Pharmacology:The Vascular System,1997,29(2):269-273
• [45]刘远嵘,顾振纶,印其章.白介素-2参与云芝糖肽镇痛作用的研究[J].浙江中医药大学学报,2009,33(6):881-882.
• [46]张玉英,龚珊,张惠琴.云芝糖肽镇痛抗炎作用的实验研究[J].苏州大学医学报,2004,24(5):652-653.
• [47]汪瑶君,钱兴南,刘海肃,包永敏.云芝糖浆治疗慢性病毒性肝炎60例疗效观察[J].中医杂志,1980(4):26-27.
• [48]梁国荣,沈吕南,陈淑斧,张君丽.云芝胞内多糖治疗慢性之型肝炎[J].新药与临床,1988,7(4):209-210.
• [49]孙设宗,唐微,张红梅,官守涛,赵杰.云芝多糖对小鼠实验性肝损伤保护作用的研究[J].中国现代医学杂志,2008,18(9):1217-1220.
• [50]李咏梅.云芝胞内多糖降血脂和抗动脉粥样硬化的实验研究[D].重庆:重庆医科大学,2002.
• [51]娄宁,陈瑗,周玫,闰道广,石益民,刘尚喜.云芝多糖对实验性动脉粥样硬化家兔的治疗作用[J].第一军医大学学报,1995,15(3):185-187.
• [52]周海华,马海乐.云芝多糖的体外抗氧化活性研究[J].食品研究与开发,2008,29(3):44-48.
• [53]莫永炎,陈玫,周瑗,姜勇.云芝多糖对脑、肝组织的抗氧化作用研究[J].中国药理学通报,2001,17(6):628-631.
• [54]张峰源,张松,曾剑锋,罗炜杰.云芝、灵芝和柱状田头菇胞外多糖对果蝇寿命的影响[J].生命科学研究,2007,11(2):130-133.
• [55]南凤仙,邵伟.云芝多糖对小鼠抗衰老作用的研究[J].宁夏大学学报,2005,26(3):264-267.
• [56]徐嘉红,邓文龙.云芝的益气解毒作用研究[J].中药药理与临床,1997,13(6):23-27.
• [57]郭志明,施为红,马岳珠.云芝多糖水提物对双歧杆菌刺激增生作用的初步研究[J].中国微生态学杂志,1995,7(6):1-3.
• [58]邓文龙,叶尚钧,王文烈,刘家玉,徐家红.云芝胞内多糖对特异性免疫功能的影响及其与免疫抑制剂合用时的免疫药理效果研究[J].抗生素,1985,10(1):47-52.
• [59]张秀峰.云芝多糖的体外抗微生物活性研究[J].吉林畜牧兽医,1994(增刊):137-139.
• [60]陈鸿珊,李壮,蒋建东,李金河,捧玉川,甄永苏.云芝多糖在小鼠体内的抗病毒和免疫促进作用[J].抗生素,1986,11(5):390-395.
• [61]Roy-Arcand L,Archibald F S.Direct dechlorination of chlorophe-nolic compounds by laccases fromTrametes(Coriolus)versicolor[J].Enzyme and Microbial Technology,1991,13(3):194-203
• [62]Muhammad Asgher,Naseema Azim,Haq Nawaz Bhatti.Decol-orization of practical textile industry effluents by white rot fungusCoriolus versicolorIBL-04[J].Biochemical Engineering Journal,2009,47(1-3):61-65.
• [63]Paul J Dodson,Christine S Evans,Pat J Harvey,John M Palmer.Production and properties of an extracellular peroxidase fromCori-olus versicolorwhich catalyses Cα-Cβcleavage in a lignin modelcompound[J].FEMS Microbiology Letters,1987,42(1):17-22.
• [64]杨海波.云芝对低阶煤的溶解作用[J].大连大学学报,1992,2(4):89-93.
• [65]罗义,刘伊丽,陈瑗,查道刚,黄晓波,刘俭.云芝多糖防止缺血再灌注心肌早期损伤[J].中国动脉硬化杂志,2002,10(2):125-128.
• [66]杭秉茜,巫冠中,吴燕,楼立青,荣沛,杨荣,杭生,杨贵成,陈亨贵,陈琼华.云芝多糖及银耳抱子多糖的抗突变作用[J].南京药学院学报,1986,17(4):305-308.
• [67]宛树军,田德荣,佟春芳.云芝肝泰治疗儿童扁平疣32例[J].中国医院药学杂志,1995,15(7):325.
• [68]徐大刚,杨杨,杨惠珍,王莉.云芝糖肽和灵芝抗小鼠弓形虫感染的实验观察[J].中国人兽共患病杂志,2003,19(4):45-46.
• [69]张玉英,李金,金杉,俞光第,顾振纶,钱曾年,杨吉成.云芝糖肽提高小鼠抗急性缺氧能力的研究[J].苏州医学院学报,1996,16(1):28-29.
• [70]梁永能,陈小君,李永强,孙艳.云芝提取液对辐射的防护作用研究[J].中草药,1999,30(8):611-612.
• [71]龚全,许国焕,付天玺,吴月嫦.云芝多糖对奥尼罗非鱼消化机能的影响[J].饲料工业,2007,28(20):21-23.
• [72]孙晓波.云芝多糖分离、纯化、药理活性及其作用机制研究[D].长春:吉林农业大学,2004.