冬虫夏草的研究进展Advances of Researches on Cordyceps sinensis
许超德;
摘要(Abstract):
冬虫夏草是著名的传统中药,具有多种药用功效。综述了近几年国内外冬虫夏草在无性型的确证、液体发酵、活性成分分离分析、药理学等方面的研究进展。
关键词(KeyWords): 冬虫夏草;无性型;液体发酵;活性成分;药理学
基金项目(Foundation):
作者(Authors): 许超德;
DOI: 10.13341/j.jfr.2006.02.013
参考文献(References):
- [1]邢来君,李明春.普通真菌学[M].北京:高等教育出版社,1999.
- [2]Chen Yueqin,Wang Ning,Qu Lianghu,et al.Determination ofthe anamorph ofCordyceps sinensisinferred from the analysis of theribosomal DNA internal transcribed spacers and 5.8S rDNA[J].Biochemical Systematic and Ecology,2001,29(6):597-607.
- [3]Chen Yueqin,Hu Bo,Xu Fei,et al.Genetic variation ofCordy-ceps sinensis,a fruit-body-producing entomopathogenic species fromdifferent geographical regions in China[J].FEMS MicrobiologyLetters,2004,230(1):153-158.
- [4]Kuo Hsiaoche,Su Yonglin,Yang Hueylang,et al.Identificationof Chinese medicinal fungusCordyceps sinensisby PCR-single-stranded conformation polymorphism andphylogenetic relationship[J].Journal of Agricultural and Food Chemistry,2005,53(10):3963-39688.
- [5]Chen Yongjiu,Zhang Yaping,Yang Yuexiong,et al.Genetic di-versity and taxonomic implication ofCordyceps sinensisas revealedby RAPD markers[J].Biochemical Genetics,1999,37(516):201-213.
- [6]Kim Hyunoh,Yun Jongwon.A comparative study on the productionof exopolysaccharides between two entomopathogenic fungi Cordy-ceps militaris andCordyceps sinensisin submerged mycelial cultures[J].Journal of Applied Microbiology,2005,99(4):728-738.
- [7]Hsieh Chienyan,Tsai MingJin,Hsu TaiHao,et al.Medium opti-mization for polysaccharide production ofCordyceps sinensis[J].Applied Biochemistry Biotechnology,2005,120(2):145-157.
- [8]Dong Caihong,Yao Yijian.Nutritional requirements of mycelialgrowth ofCordyceps sinensisin submerged culture[J].Journal ofApplied Microbiology,2005,99(3):483-492.
- [9]魏玲,赵应华,郭遂.冬虫夏草活性成分的含量研究概况.华西药学杂志[J].2003,18(5):359-360.
- [10]Huang Lanfang,Liang Yizeng,Guo Fangqiu,et al.Simultane-ous separation and determination of active components inCordy-ceps sinensisandCordyceps militarrisby LC/ESI-MS[J].Journalof Pharmaceutical and Biomedical Analysis,2003,33(5):1155-1217.
- [11]Li Shaoping,Li Ping,Dong Tina TX,et al.Determination of nu-cleosides in naturalCordyceps sinensisand culturedCordycepsmyceliaby capillary electrophoresis[J].Electrophoresis,2001,22(1):144-150.
- [12]Guo Fangqiu,Li Ai,Huang Lan-fang,et al.Identification anddetermination of nucleosides inCordyceps sinensisand its substi-tutes by high performance liquid chromatography with mass spec-trometric detection[J].Journal of Pharmaceutical and BiomedicalAnalysis,2006,40(3):623-630.
- [13]常泓,张婕.香棒虫草和冬虫夏草中甘露醇和麦角甾醇的测定分析[J].山西农业大学学报,自然科学版,2001,21(1):63-65.
- [14]李绍平,李萍,季晖,等.RP-HPLC测定天然与人工冬虫夏草游离麦角甾醇的含量[J].中国现代应用药学,2001,18(4):297-299.
- [15]刘彦威,刘娜,刘利强.冬虫夏草有效成分的研究进展[J].动物医学进展,2004,25(3):51-53.
- [16]袁建国,程显好,侯永勤.冬虫夏草多糖组分研究及药理实验[J].食品与药品,2005,7(1):45-48.
- [17]Wu Yalin,Sun Cuirong,Pan Yuanjiang.Structural analysis of aneutral(1->3),(1->4)-beta-D-glucan from the mycelia ofCordyceps sinensis[J].Journal of Natural Products,2005,68(5):812-814.
- [18]孟庆繁,林相友,李威,等.人工培养蛹虫草与野生冬虫夏草氨基酸含量的比较.氨基酸和生物资源,2005,27(2):33-35.
- [19]Wang B J,Won S,Yu Z R,et al.Free radical scavenging andapoptotic effects ofCordyceps sinensisfractionated by supercriticalcarbon dioxide[J].Food and Chemical Toxicology,2005,43(4):543-552.
- [20]Zhang Qiaoxia,Wu Jianyong,Hu Zongding,et al.Induction ofHL-60 apoptosis by ethyl acetate extract ofCordyceps sinensisfun-gal mycelium[J].Life Sciences,2004,75(24):2911-2919.
- [21]Wu Yalin,Omar I,Sun Cuirong,et al.Structure analysis andantitumor activity of(1->3)-beta-d-glucans(cordyglucans)fromthe mycelia ofCordyceps sinensis[J].Planta Medica,2005,71(4):381-384.
- [22]Bok JW,Lermer L,Chilton J,et al.Antitumor sterols from themycelia ofCordyceps sinensis[J].Phytochemistry,1999,51(7):891-898.
- [23]Nakamura K,Konoha K,Yamaguchi Y,et al.Combined effectsofCordyceps sinensisand methotrexate on hematogenic lung metas-tasis in mice[J].Receptors&Channels,2003,9(5):329-334.
- [24]Zhang Weiyun,Yang Jinyu,Chen Jiaping,et al.Immunomodula-tory and antitumour effects of an exopolysaccharide fraction fromcultivatedCordyceps sinensis(Chinese caterpillar fungus)on tu-mour-bearing mice[J].Biotechnology and Applied Biochemistry,2005,42(Pt1):9-15.
- [25]Li Shaoping,Su Ziren,Dong Tina TX,et al.The fruiting bodyand its caterpillar host ofCordyceps sinensisshow close resem-blance in main constituents and anti-oxidation activity[J].Phy-tomedicine,2002,9(4):319-324.
- [26]Li Shao ping,Zhao Kui J,Ji Zhan N,et al.A polysaccharideisolated fromCordyceps sinensis,a traditional Chinese medicine,protects PC12 cells against hydrogen peroxide-induced injury[J].Life Sciences,2003,73(19):2503-2513.
- [27]Yamaguchi Y,Kagota S,Nakamura K,et al.Antioxidant activityof the extracts from fruiting bodies of culturedCordycepssinensis[J].Phytotherapy Research,2000,14(8):647-649.
- [28]Hsu Chihchao,Huang Yuanli,Tsai Shawjeng,et al.In vivo andin vitro stimulatory effects ofCordyceps sinensison testosteroneproduction in mouse Leydig cells[J].Life Sciences,2003,73(16):2127-2136.
- [29]Huang B M,Hsu C C,Tsai S J,et al.Effects ofCordycepssinensison testosterone production in normal mouse Leydig cells[J].Life Sciences,2001,69(22):2593-2602.
- [30]Manabe N,Azuma Y,Sugimoto M,et al.Effects of the mycelialextract of culturedCordyceps sinensison in vivo hepatic energymetabolism and blood flow in dietary hypoferric anaemic mice[J].The British Journal of Nutrition,2000,83(2):197-204.
- [31]Zhang Xia,Liu Yukan,Shen Wei,et al.Dynamical influence ofCordyceps sinensison the activity of hepatic insulinase of experi-mental liver cirrhosis[J].Hepatobiliary Pancreatic Diseases Inter-national,2004,3(1):99-101.
- [32]Yamaguchi Y,Kagota S,Nakamura K,et al.Inhibitory effects ofwater extracts from fruiting bodies of culturedCordyceps sinensisonraised serum lipid peroxide levels and aortic cholesterol depositionin atherosclerotic mice[J].Phytotherapy Research,2000,14(8):650-652.
- [33]Chiou Wenfei,Chang Peiching,Chou Chengjen,et al.Proteinconstituent contributes to the hypotensive and vasorelaxant activi-ties ofCordyceps sinensis[J].Life Sciences,2000,66(14):1369-1376.
- [34]Kuo C F,Chen C C,Luo Y H,et al.Cordyceps sinensismyceli-um protects mice from group A streptococcal infection[J].Joumalof Medical Microbiology,2005,54(8):795-802.
- [35]Koh J H,Suh H J,Ahn T S.Hot-water extract from mycelia ofCordyceps sinensisas a substitute for antibiotic growth promoters[J].Biotechnology Letters,2003,25(7):585-590.
- [36]Kuo Y C,Tsai W J.Regulation of bronchoalveolar lavage fluidscell function by the immunomodulatory agents fromCordycepssinensis[J].Life Sciences,2001,68(9):1067-1082.
- [37]靳朝霞,杨少辉,李明刚,等.冬虫夏草的研究进展与发展趋势[J].天津医科大学学报,2005,11(1):137-140.