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韧革菌素（Vibralactone）是从韧革菌科Stereaceae真菌中分离得到的具有β-内酯双环骨架结构的天然产物。该化合物具有良好的胰脂肪酶抑制活性，具有开发成为新型减肥药物的潜力。其独特的结构特征和良好的生物活性，引起了国内外学者的广泛关注。文章总结了韧革菌素类化合物的化学结构、生物活性及其化学和生物合成的研究进展，并基于现有的研究基础，对韧革菌素生物合成和应用前景及潜在的技术突破进行了讨论和展望。将为韧革菌素类化合物在医药研发、化学合成和生物合成领域的研究提供重要参考。
Abstract：Vibralactone is a natural product isolated from a fungus of the species Stereaceae to have a β-fused bicyclic lactone backbone structure. This compound is known to have a good inhibitory activity against the pancreatic lipase, indicating its potential value for development of a newtype obesity drug. It has attracted extensive attention from experts and scholars around the world because of its unique structural features and good biological activity. This paper summarizes the advances of research on the chemical structure and synthesis, biological activity and biosynthesis of vibralactone and its analogues as well. Basing on the current results and research foundation, we also carry out discussions together with future prospects in the development and application as well as potential technological breakthroughs of vibralactone biosynthesis in this review, which should provide available references for the drug exploration, chemical synthesis and biosynthesis of this substance and its derivatives.
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基本信息:
DOI：10.13341/j.jfr.2024.1711
中图分类号:Q936
引用信息:
[1]闫新元,张璇,段应策等.韧革菌素类化合物结构特征、生物活性及生物合成研究进展[J].菌物研究,2025,23(02):141-150.DOI:10.13341/j.jfr.2024.1711.
基金信息:
中央高校基本科研业务专项资金项目（2572023AW40）; 泰山学者专家计划项目（tsqn2021030130）